ANTIHYPER LIPIDEMIC EFFECT OF POLY HERBAL FORMULATION IN ALBINO RATS USING TRITON-X AND FAT DIET INDUCED HYPERLIPIDEMIC MODELS

Authors

  • Mohd Ahmed Uddin Department of Pharmacology, AZAD College of pharmacy, Moinabad, Telangana-501504
  • Roshan. S Department of Pharmacology, AZAD College of pharmacy, Moinabad, Telangana-501504
  • N. L. Mahammed Department of Pharmacology, AZAD College of pharmacy, Moinabad, Telangana-501504
  • Mohd Altaf Ahmed Khan Department of Pharmacology, AZAD College of pharmacy, Moinabad, Telangana-501504

Keywords:

Triton, fat diet, hyperlipidemia, Polyherbal formulation, Atrovastatin

Abstract

The anti-hyperlipidemic effect of Polyherbal formulation (PHF) was tested in Triton and fat diet induced hyperlipidemic rat models. Here, Acute hyperlipidemia was induced by administration of single dose of Triton X 100 (400 mg/kg,i.p) and Chronic hyperlipidemia was induced by feeding fat diet for 21 days to rats. Treatment with Polyherbal formulation (PHF) (200 and 400 mg/kg, p.o ) significantly reduced the hyperlipidemia i.e., decreased levels of serum Total Cholesterol, Triglycerides, Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C) , an increase of serum High Density Lipoprotein Cholesterol (HDL-C) when compared to vehicle control and standard drug Atorvastatin (10 mg/kg). The results demonstrated that Polyherbal formulation (PHF) possessed significant antihyperlipidemic activity.

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Published

2016-03-15

How to Cite

Uddin, M. A. ., Roshan. S, Mahammed, N. L. ., & Khan, M. A. A. . (2016). ANTIHYPER LIPIDEMIC EFFECT OF POLY HERBAL FORMULATION IN ALBINO RATS USING TRITON-X AND FAT DIET INDUCED HYPERLIPIDEMIC MODELS. International Journal of Research and Development in Pharmacy & Life Sciences, 5(2), 2088-2091. Retrieved from https://www.ijrdpl.com/index.php/ijrdpl/article/view/223